(S)-1-苄基-3-甲烷氧基吡咯烷合成路线 （共 14 条）
反应条件
sodium hydroxide in tetrahydrofuran; tert-butyl methyl ether
参考文献
Hoffmann-La Roche Inc.
Patent: US5977381 A1, 1999 ;
反应条件
1: Et3N / tetrahydrofuran / 1 h / -3 °C
2: H2 / 20percent Pd(OH)2/C / ethanol / 0.33 h / 757.6 Torr
View Scheme
参考文献
Thomas, Christoph; Orecher, Florian; Gmeiner, Peter
Synthesis, 1998 , # 10 p. 1491 - 1496
反应条件
hydrogen; triethylamine; palladium dihydroxide
1.) THF, -3 deg C, 1 h, 2.) EtOH, 20 min, 1010 mbar; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Thomas, Christoph; Orecher, Florian; Gmeiner, Peter
Synthesis, 1998 , # 10 p. 1491 - 1496
反应条件
1: 90 percent / 85percent H3PO4 / diethyl ether; H2O / 3 h
2: nBuLi / tetrahydrofuran / 1) -78 deg C to r.t., 2) r.t., 15 min
View Scheme
参考文献
Nagel, Ulrich; Nedden, Hans Guenter
Chemische Berichte, 1997 , vol. 130, # 3 p. 385 - 397
