(R)-β-(Cbz-氨基)-γ-丁内酯合成路线 （共 14 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=0 - 20°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=2;
参考文献
WO2009/36051 A1, ;
Page/Page column 48 ;
WO 2009/036051 A1
反应条件
toluene-4-sulfonic acid in toluene 3 h; Dean-Stark conditionsReflux;
参考文献
US2012/35134 A1, ;
Page/Page column 9; 32 ;
反应条件
samarium diiodide in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 29 p. 5705 - 5713
反应条件
toluene-4-sulfonic acid in benzene Heating;
参考文献
Tetrahedron Letters, , vol. 32, # 7 p. 923 - 926
反应条件
1: SOCl2 2: 1.) NaBH4, 2.) p-TsOH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 9 p. 2349 - 2357
反应条件
1: N-methylmorpholine / 1,2-dimethoxy-ethane / 0.02 h / -15 °C 2: NaBH4 / H2O; 1,2-dimethoxy-ethane / 0.01 h / -15 °C 3: 78 percent / p-TosOH / benzene / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 7 p. 923 - 926
参考文献
Journal of the American Chemical Society, , vol. 110, # 25 p. 8557 - 8558
反应条件
1: TFA 2: NaIO4 3: NaBH4 4: p-TsOH View Scheme
参考文献
Chemistry Letters, , # 5 p. 793 - 794
反应条件
1: (R)-4-benzyloxycarbonylamino-4,5-dihydro-2(3H)-furanone; dimethyl amine in tetrahydrofuran T=100°C; 0.333333 h; Microwave irradiation; 2: diphenyldisulfane With tributylphosphine in toluene T=105°C; 0.416667 h; Microwave irradiation;
参考文献
Eswaran, Sumesh; Adhikari, Airody Vasudeva; Pal, Nishith K.; Chowdhury, Imran H.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1040 - 1044
反应条件
1: tetrahydrofuran / 14 h / 18 - 25 °C 2: tributylphosphine / toluene / 8 h / 80 °C View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
