(R)-β-(Cbz-氨基)-γ-丁内酯合成路线 （共 14 条）
参考文献
CURIS, INC.
Patent: WO2009/36051 A1, 2009 ;
Location in patent: Page/Page column 48 ;
WO 2009/036051 A1
反应条件
in tetrahydrofuran
T=20°C; 16 h;
参考文献
Elmore, Steven W.; Bruncko, Milan; Park, Cheol-Min
Patent: US2005/272744 A1, 2005 ;
Location in patent: Page/Page column 11 ;
US 20050272744 A1
反应条件
in 1,4-dioxane
T=70°C; 18 h;
参考文献
Elmore, Steven W.; Bruncko, Milan; Park, Cheol-Min
Patent: US2005/272744 A1, 2005 ;
Location in patent: Page/Page column 20 ;
US 20050272744 A1
反应条件
1: tetrahydrofuran / 18 - 25 °C
2: tributylphosphine / toluene / 80 °C / Inert atmosphere
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参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
