6-溴-3-羟基-2-甲基吡啶合成路线 （共 7 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h;
参考文献
Hadida Ruah, Sara Sabina; Kallel, Edward Adam; Miller, Mark Thomas; Arumugam, Vijayalaksmi; McCartney, Jason; Anderson, Corey; Grootenhuis, Peter Diederik Jan; Jiang, Licong
Patent: US2012/196869 A1, 2012 ;
Location in patent: Paragraph 0338; 0339 ;
US 20120196869 A1
反应条件
sodium hydroxide; bromine T=20°C;
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
反应条件
N-bromosuccinmide in acetonitrile Title compound not separated from byproducts;
参考文献
Synlett, , # 11 p. 1678 - 1682
反应条件
1: With sodium hydride in tetrahydrofuran T=20°C; 0.5 h; 2: With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 1 h; 3: With methanol-d4 in tetrahydrofuran T=-78 - 20°C;
参考文献
Shimizu, Haruka; Manabe, Kei
Tetrahedron Letters, 2006 , vol. 47, # 33 p. 5927 - 5931
反应条件
1: 91 percent / methanol; CH2Cl2 / 20 °C
2: 84 percent / mCPBA / CHCl3 / 18 h / Heating
3: aq. NaOH / 0.33 h / 150 °C / 9000.72 Torr / microwave irradiation
View Scheme
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
反应条件
potassium carbonate in acetone
16 h; Heating;
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
反应条件
in methanol; dichloromethane
T=20°C;
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
