3-环丁基-3-氧代-丙腈合成路线 （共 6 条）
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.5 h; 2: ethyl cyclobutane carboxylate in tetrahydrofuran; hexane T=-78 - -45°C; 3.33333 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2005/303 A1, 2005 ;
Location in patent: Page 20 ;
WO 2005/000303 A1
反应条件
in ethanol; ethyl acetate
参考文献
Sanner, Mark A.; Helal, Chris J.; Cooper, Christopher B.; Wager, Travis T.
Patent: US2002/103185 A1, 2002 ;
反应条件
sodium chloride in water; dimethyl sulfoxide
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2 h; Inert atmosphere;
参考文献
Johnson, Leland; Powers, James; Ma, Fupeng; Jendza, Keith; Wang, Bing; Meredith, Erik; Mainolfi, Nello
Synthesis (Germany), 2013 , vol. 45, # 2 p. 171 - 173
反应条件
hydrazine in ethanol T=75°C; 14 h;
参考文献
Pfizer Inc
Patent: US2004/266815 A1, 2004 ;
Location in patent: Page 11-12 ;
US 20040266815 A1
反应条件
in ethanol
5 h; Heating;
参考文献
Adachi; Yamamori; Hiramatsu; Sakai; Sato; Kawakami; Uno; Ueda
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3235 - 3252
