4,6-二氯-1-(四氢-吡喃-4-基)-1H-吡唑并[3,4-d]嘧啶合成路线 （共 6 条）
反应条件
1: With triethylamine in ethanol T=-78°C; 0.5 h; 2: With hydrogenchloride in ethanol; water T=0°C; pH=5 - 6;
参考文献
TYROGENEX, INC.; LIANG, Congxin
Patent: WO2011/41399 A2, 2011 ;
Location in patent: Page/Page column 48-49 ;
WO 2011/041399 A2
反应条件
triethylamine T=-78 - 0°C; 3 h; Inert atmosphere;
参考文献
AMBIT BIOSCIENCES CORPORATION; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ROWBOTTOM, Martin
Patent: WO2012/30924 A1, 2012 ;
Location in patent: Page/Page column 144-145 ;
WO 2012/030924 A1
反应条件
N-ethyl-N,N-diisopropylamine in ethanol
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Jianwen; HAYNES, Nancy-Ellen; HERMANN, Johannes Cornelius; KIM, Kyungjin; LIU, Jin-Jun; SCOTT, Nathan Robert; YI, Lin; ZAK, Mark; ZHAO, Guiling
Patent: WO2013/182546 A1, 2013 ;
Location in patent: Page/Page column 139; 140 ;
反应条件
1: methanol / 1.5 h / 20 °C 2: sodium cyanoborohydride / acetic acid / 1.5 h / 20 °C 3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 4: triethylamine / ethanol / 1 h / -78 - 0 °C View Scheme
参考文献
TYROGENEX, INC.; LIANG, Congxin
Patent: WO2011/41399 A2, 2011 ;
WO 2011/041399 A2
反应条件
1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 2: triethylamine / ethanol / 1 h / -78 - 0 °C View Scheme
参考文献
TYROGENEX, INC.; LIANG, Congxin
Patent: WO2011/41399 A2, 2011 ;
WO 2011/041399 A2
反应条件
1: sodium cyanoborohydride / acetic acid / 1.5 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3: triethylamine / ethanol / 1 h / -78 - 0 °C View Scheme
参考文献
TYROGENEX, INC.; LIANG, Congxin
Patent: WO2011/41399 A2, 2011 ;
WO 2011/041399 A2
