1-哌啶-4-基-1H-吲哚合成路线 （共 17 条）
反应条件
triethylamine in dichloromethane
参考文献
Eli Lilly and Company
Patent: US5545636 A1, 1996 ;
US 5545636 A
反应条件
1.1: 97 percent / K2CO3 / dimethylformamide / 5 h / 20 - 50 °C 2.1: HCl gas / acetonitrile / 0.5 h / 0 - 20 °C 2.2: acetonitrile / 2 h / -10 - 0 °C 2.3: 86.5 percent / acetonitrile / 1 h / -10 - 0 °C 3.1: 75 percent / t-BuOK / tetrahydrofuran / -5 - 45 °C View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
hydrogen; palladium on activated charcoal in methanol
P=2585.74 Torr; 20 h;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
trifluoroacetic acid in ethyl acetate
T=60°C; 12 h;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 83 percent / NaBH(OAc)3 / acetic acid / 19 h / 20 - 50 °C
2: 98 percent / H2 / Pd/C / methanol / 20 h / 2585.74 Torr
View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 84 percent / TMSCl / 22 h / Heating
2: 100 percent / H2 / Pd/C / methanol / 20 °C / 1034.3 - 2585.74 Torr
3: 83 percent / NaBH(OAc)3 / acetic acid / 19 h / 20 - 50 °C
4: 98 percent / H2 / Pd/C / methanol / 20 h / 2585.74 Torr
View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 100 percent / H2 / Pd/C / methanol / 20 °C / 1034.3 - 2585.74 Torr
2: 83 percent / NaBH(OAc)3 / acetic acid / 19 h / 20 - 50 °C
3: 98 percent / H2 / Pd/C / methanol / 20 h / 2585.74 Torr
View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
sodium hydroxide in ethylene glycol
T=150°C;
参考文献
Sasakura, Kazuyuki; Adachi, Makoto; Sugasawa, Tsutomu
Synthetic Communications, 1988 , vol. 18, # 3 p. 265 - 274
反应条件
1: 99 percent / NaBH(OAc)3 / acetic acid / 1 h / 20 °C
2: 88 percent / DDQ / tetrahydrofuran / 0.75 h / 0 - 5 °C
3: 70 percent / TFA / ethyl acetate / 12 h / 60 °C
View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 99 percent / NaBH(OAc)3 / acetic acid / 1 h / 20 °C
2: 88 percent / DDQ / tetrahydrofuran / 0.75 h / 0 - 5 °C
3: 70 percent / TFA / ethyl acetate / 12 h / 60 °C
View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
