1-哌啶-4-基-1H-吲哚合成路线 （共 17 条）
反应条件
1: 88 percent / DDQ / tetrahydrofuran / 0.75 h / 0 - 5 °C
2: 70 percent / TFA / ethyl acetate / 12 h / 60 °C
View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: BCl3
2: NaBH4, 1N NaOH / aq. ethanol / 1 h / ice cooling
3: dioxane / 2 h / Heating
4: 82 percent / 1,2-dichloro-ethane / 2 h / Heating
5: 50percent NaOH / ethane-1,2-diol / 150 °C
View Scheme
参考文献
Sasakura, Kazuyuki; Adachi, Makoto; Sugasawa, Tsutomu
Synthetic Communications, 1988 , vol. 18, # 3 p. 265 - 274
反应条件
1: 82 percent / 1,2-dichloro-ethane / 2 h / Heating
2: 50percent NaOH / ethane-1,2-diol / 150 °C
View Scheme
参考文献
Sasakura, Kazuyuki; Adachi, Makoto; Sugasawa, Tsutomu
Synthetic Communications, 1988 , vol. 18, # 3 p. 265 - 274
反应条件
1: NaBH4, 1N NaOH / aq. ethanol / 1 h / ice cooling
2: dioxane / 2 h / Heating
3: 82 percent / 1,2-dichloro-ethane / 2 h / Heating
4: 50percent NaOH / ethane-1,2-diol / 150 °C
View Scheme
参考文献
Sasakura, Kazuyuki; Adachi, Makoto; Sugasawa, Tsutomu
Synthetic Communications, 1988 , vol. 18, # 3 p. 265 - 274
反应条件
1: sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
View Scheme
参考文献
Yang, Shyh-Ming; Tang, Yuting; Rano, Thomas; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Lang, Wensheng; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 5 p. 1437 - 1441
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 50°C; 5 h;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
