N-[(1S)-1-(氨基羰基)-2-甲基丙基]-1-[(4-氟苯基)甲基]-1H-吲唑-3-甲酰胺合成路线 （共 4 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=18 - 25°C; 18 h;
参考文献
Pfizer Inc.
Patent: US2011/28447 A1, 2011 ;
Location in patent: Page/Page column 34 ;
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 25 °C / Cooling with ice 1.2: 5 h / 0 - 20 °C 2.1: sodium hydroxide / methanol / 12 h / 18 - 25 °C 3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 18 - 25 °C View Scheme
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 25 °C / Cooling with ice 1.2: 5 h / 0 - 20 °C 2.1: sodium hydroxide / methanol / 12 h / 18 - 25 °C 3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 18 - 25 °C View Scheme
反应条件
1: sodium hydroxide / methanol / 12 h / 18 - 25 °C 2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 18 - 25 °C View Scheme
