反应条件
1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide / ethyl acetate; acetonitrile; water / -5 - 30 °C / Industry scale
2: sodium acetate; sodium hypochlorite; acetic acid; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / methyl acetate; water; tert-butyl methyl ether / 2 h / 5 - 15 °C / Industry scale
View Scheme
参考文献
SCHERING CORPORATION; TRAVERSE, John; LEONG, William, W.; MILLER, Steven, P.; ALBANEZE-WALKER, Jennifer; HUNTER, Thomas, J.; WANG, Lijun; LIAO, Hongbiao; ARASAPPAN, Ashok; TRZASKA, Scott, T.; SMITH, Randi, M.; LEKHAL, Azzeddine; BOGEN, Stephane, L.; KONG, Jianshe; BENNETT, Frank; NJOROGE, F., George; POIRIER, Marc; KUO, Shen-Chun; CHEN, Yonggang; MATTHEWS, Kenneth S.; DEMONCHAUX, Patrice; FERREIRA, Amadeo
Patent: WO2011/14494 A1, 2011 ;