1: ammonia / isopropyl alcohol; water / 20 h / 100 °C / 31029.7 Torr 2: hydrogenchloride / methanol / 2 h / 65 °C View Scheme

Multi-step reaction with 3 steps 1.1: triethylamine / N,N-dimethyl-formamide / 60 °C2.1: trifluoroacetic anhydride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C2.2: 0.5 h3.1: trifluoroacetic acid; pyridine / toluene / 0.5 h / 0 °C3.2: 20 h / 15 °C  

Multi-step reaction with 2 steps 1.1: trifluoroacetic anhydride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C1.2: 0.5 h2.1: trifluoroacetic acid; pyridine / toluene / 0.5 h / 0 °C2.2: 20 h / 15 °C  

With  ammonia in  water; isopropyl alcohol T=100°C; P=31029.7 Torr; 20 h;  Show Experimental Procedure