1-甲基-1H-吲哚-2-羰酰氯合成路线 （共 15 条）
反应条件
thionyl chloride in dichloromethane
参考文献
Urwyler, Stephan; Floersheim, Philipp; Roy, Bernard L.; Koller, Manuel
Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5093 - 5107
反应条件
in dichloromethane; N,N-dimethyl-formamide
参考文献
Abbott Laboratories
Patent: US6921763 B2, 2005 ;
反应条件
1: 96 percent / H2SO4 / 23 h / Heating 2: NaH / tetrahydrofuran / 15.5 h / 0 °C 3: 1.96 g / KOH; H2O / methanol / 16 h / Heating 4: SOCl2 / dioxane / 6 h / Heating View Scheme
参考文献
Organic Letters, , vol. 7, # 21 p. 4777 - 4779
反应条件
1: NaH / tetrahydrofuran / 15.5 h / 0 °C 2: 1.96 g / KOH; H2O / methanol / 16 h / Heating 3: SOCl2 / dioxane / 6 h / Heating View Scheme
参考文献
Organic Letters, , vol. 7, # 21 p. 4777 - 4779
反应条件
1: 1.96 g / KOH; H2O / methanol / 16 h / Heating 2: SOCl2 / dioxane / 6 h / Heating View Scheme
参考文献
Organic Letters, , vol. 7, # 21 p. 4777 - 4779
反应条件
1: 86 percent / aq. KOH / ethanol / 0.5 h / Heating 2: SOCl2 / dioxane / 25 - 30 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 12 p. 963 - 972
反应条件
oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide
参考文献
Journal of the American Chemical Society, , vol. 136, # 9 p. 3354 - 3357
反应条件
1: 93 percent / diethyl ether; dioxane; H2O / 3 h / Ambient temperature 2: 80 percent / lithium aluminium hydride / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Cruces; Elorriaga; Fernandez Alvarez; Lopez Chico; Nieto Lopez
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 7-8 p. 567 - 573
反应条件
1: CH2Cl2 / 20 °C 2: 94 percent / MnO2; glacial acetic acid / CH2Cl2 / 8 h / 20 °C View Scheme
参考文献
Romero; Pujol
Synlett, 2003 , # 2 p. 173 - 178
