4-羟基-2-氧代-1,2-二氢-1,8-萘啶-3-羧酸乙酯合成路线 （共 3 条）
反应条件
sodium ethanolate in ethanol 6 h; Reflux;
参考文献
Manera, Clementina; Saccomanni, Giuseppe; Malfitano, Anna Maria; Bertini, Simone; Castelli, Francesca; Laezza, Chiara; Ligresti, Alessia; Lucchesi, Valentina; Tuccinardi, Tiziano; Rizzolio, Flavio; Bifulco, Maurizio; Di Marzo, Vincenzo; Giordano, Antonio; MacChia, Marco; Martinelli, Adriano
European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 284 - 294
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphereSealed tube; 2: 2-Methyl-4H-pyridolt;2,3-dgt;lt;3,1gt;oxazin-4-one in tetrahydrofuran; mineral oil T=70°C; 0.166667 h; Inert atmosphereSealed tubeMicrowave irradiation;
参考文献
Prousis, Kyriakos C.; Tzani, Andromachi; Avlonitis, Nicolaos; Calogeropoulou, Theodora; Detsi, Anastasia
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1313 - 1321
反应条件
1.1: 1 h / 170 °C 2.1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C / |Inert atmosphere; |Sealed tube 2.2: 0.17 h / 70 °C / |Inert atmosphere; |Sealed tube; |Microwave irradiation View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 50, # 6 p. 1313 - 1321
