copper(l) iodide in N,N-dimethyl-formamide T=100°C; 5 h; Sealed tube;

copper(l) iodide; fluorosulfonyl(difluoro)acetic acid methyl ester in N,N-dimethyl-formamide T=100°C; 5 h; Sealed tube;

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 °C / Inert atmosphere 2.1: copper(l) iodide; fluorosulfonyl(difluoro)acetic acid methyl ester / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed tube View Scheme

1: benzyl alcohol With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.0333333 h; 2: 2,4-dichloro-3-(trifluoromethyl)pyridine T=0 - 20°C; 1 h;

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C 2.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / |Microwave irradiation 3.1: triethylamine / dichloromethane / 1 h / 20 °C 3.2: 150 °C / |Microwave irradiation 4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 180 °C / |Microwave irradiation View Scheme