3-(2H-四唑-5-基)吡咯烷-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
sodium azide; ammonium chloride in N,N-dimethyl-formamide T=120°C; 18 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; CHU, Lin; OGAWA, Anthony; OK, Hyun, O.; UJJAINWALLA, Feroze
Patent: WO2010/51245 A1, 2010 ;
Location in patent: Page/Page column 51 ;
WO 2010/051245 A1
反应条件
1: With sodium azide; ammonium chloride in N,N-dimethyl-formamide T=120°C; 18 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; OGAWA, Anthony; OK, Hyun, O.; ONDEYKA, Debra; UJJAINWALLA, Feroze; VANDE BUNTE, Ellen
Patent: WO2010/77624 A1, 2010 ;
Location in patent: Page/Page column 49 ;
WO 2010/077624 A1
反应条件
potassium carbonate in acetonitrile 3 h; Reflux;
参考文献
MERCK SHARP andamp; DOHME CORP.; OGAWA, Anthony; OK, Hyun, O.; ONDEYKA, Debra; UJJAINWALLA, Feroze; VANDE BUNTE, Ellen
Patent: WO2010/77624 A1, 2010 ;
Location in patent: Page/Page column 49-50 ;
WO 2010/077624 A1
