4-氯-5-氟-2-硝基甲苯合成路线 （共 7 条）
反应条件
hydrazine hydrate in tetrahydrofuran; methanol; water; N,N-dimethyl-formamide
参考文献
Vernalis Research Limited
Patent: US6380238 B1, 2002 ;
反应条件
1: dimethylformamide / 2 h / 130 °C 2: 124 g / hydrazine hydrate; Raney nickel / tetrahydrofuran; methanol; dimethylformamide / 16 h / 20 °C View Scheme
参考文献
Bentley, Jon M.; Davidson, James E.; Duncton, Matthew A. J.; Giles, Paul R.; Pratt, Robert M.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2295 - 2300
反应条件
1: in N,N-dimethyl-formamide T=125°C; 3 h; 2: With iron; acetic acid in ethanol T=90°C; 2 h;
参考文献
Gaisina, Irina N.; Gallier, Franck; Ougolkov, Andrei V.; Kim, Ki H.; Kurome, Toru; Guo, Songpo; Holzle, Denise; Luchini, Doris N.; Blond, Sylvie Y.; Billadeau, Daniel D.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 7 p. 1853 - 1863
反应条件
1: T=140°C; 2: With nickel; hydrazine hydrate in methanol T=20°C; Leimgruber-Batcho reaction;
参考文献
Bentley, Jon M.; Davidson, James E.; Duncton, Matthew A. J.; Giles, Paul R.; Pratt, Robert M.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2295 - 2300
参考文献
Bentley, Jon M.; Davidson, James E.; Duncton, Matthew A. J.; Giles, Paul R.; Pratt, Robert M.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2295 - 2300
反应条件
1: T=140°C;
2: With nickel; hydrazine hydrate in methanol
T=20°C; Leimgruber-Batcho reaction;
参考文献
Bentley, Jon M.; Davidson, James E.; Duncton, Matthew A. J.; Giles, Paul R.; Pratt, Robert M.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2295 - 2300
反应条件
1: in N,N-dimethyl-formamide
T=125°C; 3 h;
2: With iron; acetic acid in ethanol
T=90°C; 2 h;
参考文献
Gaisina, Irina N.; Gallier, Franck; Ougolkov, Andrei V.; Kim, Ki H.; Kurome, Toru; Guo, Songpo; Holzle, Denise; Luchini, Doris N.; Blond, Sylvie Y.; Billadeau, Daniel D.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 7 p. 1853 - 1863
