4-氯-3-碘-1H-吡唑[4,3-c]吡啶合成路线 （共 4 条）
反应条件
iodine; potassium hydroxide in 1,4-dioxane T=75°C; 4 h;
参考文献
MEDICAL RESEARCH COUNCIL TECHNOLOGY; GENENTECH INC.; CHAN, Bryan; CHEN, Huifen; ESTRADA, Anthony; SHORE, Daniel; SWEENEY, Zachary; McIVER, Edward
Patent: WO2012/38743 A1, 2012 ;
Location in patent: Page/Page column 82 ;
WO 2012/038743 A1
反应条件
1: hydrazine hydrate / ethylene glycol dimethyl ether / 20 - 75 °C 2: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 75 °C View Scheme
参考文献
WO2012/38743 A1, ;
WO 2012/038743 A1
反应条件
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 3.5 h / -78 - 0 °C 1.2: 1.5 h / -78 °C 2.1: hydrazine hydrate / ethylene glycol dimethyl ether / 20 - 75 °C 3.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 75 °C View Scheme
参考文献
WO2012/38743 A1, ;
WO 2012/038743 A1
反应条件
potassium hydroxide in N,N-dimethyl-formamide T=20°C; 2.5 h;
参考文献
WO2010/106333 A1, ;
Page/Page column 79 ;
WO 2010/106333 A1
