反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: 1) BCl<sub>3</sub>, 2) AlCl<sub>3</sub> / 1) CH<sub>2</sub>Cl<sub>2</sub>, -50 deg C, 30 min, 2a) -50 deg C, 1h, b) rt, 18 h, c)40 deg C, 3 h<br />2: 63 percent / AlCl<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 22 h / Ambient temperature<br />3: 87 percent / K<sub>2</sub>CO<sub>3</sub> / acetone / 18 h / Heating<br /> <br />
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
