3-(N-boc-氨基)苄醇合成路线 (共 7 条)
反应条件
in tetrahydrofuran T=25 - 80°C; 21 h;
参考文献
Berthel, Steven Joseph; Kester, Robert Francis; Murphy, Douglas Eric; Prins, Thomas Jay; Ruebsam, Frank; Sarabu, Ramakanth; Tran, Chinh Viet; Vourloumis, Dionisios
Patent: US2008/21032 A1, 2008 ;
Location in patent: Page/Page column 56 ;
US 20080021032 A1
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 6 h;
参考文献
Nasim, Shama; Guzman, Monica L.; Jordan, Craig T.; Crooks, Peter A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4879 - 4883
反应条件
1: hydrogenchloride / water / 1 h 2: sodium azide; tetrabutylammomium bromide / acetone / 0.5 h 3: triphenylphosphine / tetrahydrofuran; water / 5 h View Scheme
参考文献
Nasim, Shama; Guzman, Monica L.; Jordan, Craig T.; Crooks, Peter A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4879 - 4883
反应条件
water T=110°C; 1.5 h;
参考文献
Wang, Jia; Liang, Yan-Liang; Qu, Jin
Chemical Communications, 2009 , # 34 p. 5144 - 5146
反应条件
1: 74 percent / CBr4, Ph3P / CH2Cl2 / 1.5 h / 0 °C 2: 92 percent / K2CO3 / acetone / 12 h / Heating 3: 82 percent / CF3CO2H / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Brown, Frederick J.; Bernstein, Peter R.; Cronk, Laura A.; Dosset, David L.; Hebbel, Kevin C.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 811 - 826
反应条件
triethanolamine in dichloromethane; water; dimethyl sulfoxide
参考文献
Ko, Sung-Bo; Oh, Eu-Gene; Kim, Eon-Kyeom; Kim, Won-Yeob; Choi, Dennis W.; Dugan, Laura L.; Koh, Jae-Young; Won, Moo-Ho; Wie, Myung-Bok
Patent: US2003/220337 A1, 2003 ;
反应条件
manganese(IV) oxide in dichloromethane
参考文献
Aboaku, Safo; Paduan-Filho, Armando; Bindilatti, Valdir; Oliveira, Nei Fernandes; Schlueter, John A.; Lahti, Paul M.
Chemistry of Materials, 2011 , vol. 23, # 21 p. 4844 - 4856