1: With water; sodium hydroxide in isopropyl alcohol T=100°C; 24 h; 2: With hydrogenchloride in water

Multi-step reaction with 5 steps 1.1: Candida antarctica Lipase A / tetrahydrofuran / 5 h / 30 °C / Enzymatic reaction2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere2.2: 10 h / -25 - -15 °C3.1: water; triphenylphosphine / 15 h / 65 °C4.1: triethylamine / dichloromethane / 1 h / 20 °C5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C5.2: 1 h / 20 °C