N-(2-氰基-3-乙氧基-1-氧代-2-丙烯-1-基)-氨基甲酸乙酯合成路线 （共 20 条）
反应条件
orthoformic acid triethyl ester 2.5 h; Heating / reflux;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2006/25433 A1, 2006 ;
Location in patent: Page/Page column 103 ;
US 20060025433 A1
反应条件
in acetonitrile T=80°C; 4 h;
参考文献
Zhuang, Bo-Ren; Hsu, Gien-Jow; Sung, Kuangsen
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 10 p. 3399 - 3404
参考文献
Journal of Physical Organic Chemistry, , vol. 18, # 12 p. 1183 - 1189
反应条件
1: With sodium hydroxide; ammonium hydroxide in water T=25 - 70°C; 1.16667 h; 2: With hydrogenchloride in water pH=4;
参考文献
Shaw
Journal of the Chemical Society, 1955 , p. 1834,1838
参考文献
Atkinson et al.
Journal of the Chemical Society, 1956 , p. 4118,4120
反应条件
in 1,2,3,4-tetrahydro-naphthalene
参考文献
Zoecon Corporation; Imperial Chemical Industries Limited
Patent: US4266056 A1, 1981 ;
反应条件
1: 96 percent / ethanol 2: 94 percent / 1,2,3,4-tetrahydro-naphthalene / 0.5 h / 185 - 200 °C View Scheme
参考文献
Hirota; Sajiki; Kitade; Maki
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 2008 - 2011
反应条件
1: 96 percent / CDCl3 / 24 h / 25 °C 2: 96 percent / triethylamine / CD3CN / 4 h / 80 °C View Scheme
参考文献
Zhuang, Bo-Ren; Hsu, Gien-Jow; Sung, Kuangsen
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 10 p. 3399 - 3404
参考文献
Shaw
Journal of the Chemical Society, 1955 , p. 1834,1838
参考文献
Richardson-Merrell Inc.
Patent: US3956288 A1, 1976 ;
