5-氨基-2-(2,6-二氟苯基)噻唑-4-羧酸乙酯合成路线 （共 4 条）
反应条件
Lawesson's reagent in pyridine 18 h; Inert atmosphereReflux;
参考文献
NOVARTIS AG; BURGER, Matthew; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TAMEZ, JR., Victoriano; TANNER, Huw; WAN, Lifeng
Patent: WO2014/33631 A1, 2014 ;
Location in patent: Page/Page column 76 ;
反应条件
1: sodium hydrogencarbonate; sodium dithionite / water / 1.17 h / 20 °C 2: pyridine / dichloromethane / 3 h / 0 - 20 °C 3: Lawesson's reagent / toluene / 48 h / 95 °C View Scheme
参考文献
NOVARTIS AG; BURGER, Matthew; DRUMM III, Joseph; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TAFT, Benjamin; TANNER, Huw
Patent: WO2013/175388 A1, 2013 ;
反应条件
1: pyridine / dichloromethane / 3 h / 0 - 20 °C 2: Lawesson's reagent / toluene / 48 h / 95 °C View Scheme
参考文献
NOVARTIS AG; BURGER, Matthew; DRUMM III, Joseph; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TAFT, Benjamin; TANNER, Huw
Patent: WO2013/175388 A1, 2013 ;
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in dichloromethane 1 h; 2: With water; lithium hydroxide hydrate in tetrahydrofuran T=55°C; 48 h;
参考文献
NOVARTIS AG; BURGER, Matthew; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TAMEZ, JR., Victoriano; TANNER, Huw; WAN, Lifeng
Patent: WO2014/33631 A1, 2014 ;
Location in patent: Page/Page column 76-77 ;
