2,9-二氮杂螺[5.5]-1-十一酮盐酸盐合成路线 （共 3 条）
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 18 h;
参考文献
NOVARTIS AG; BADIGER, Sangamesh; BEHNKE, Dirk; BETSCHART, Claudia; CHAUDHARI, Vinod; COTESTA, Simona; HINRICHS, Juergen Hans-Hermann; OFNER, Silvio; PANDIT, Chetan; WAGNER, Juergen
Patent: WO2011/76747 A1, 2011 ;
Location in patent: Page/Page column 56 ;
WO 2011/076747 A1
反应条件
1: hydrogen; ammonia / ethanol / 48 h / 20 °C / 5171.62 Torr / |Autoclave 2: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Betschart, Claudia; Hintermann, Samuel; Behnke, Dirk; Cotesta, Simona; Fendt, Markus; Gee, Christine E.; Jacobson, Laura H.; Laue, Grit; Ofner, Silvio; Chaudhari, Vinod; Badiger, Sangamesh; Pandit, Chetan; Wagner, Juergen; Hoyer, Daniel
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7590 - 7607
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere 1.2: 4 h / -78 - -60 °C / |Inert atmosphere 2.1: hydrogen; ammonia / ethanol / 48 h / 20 °C / 5171.62 Torr / |Autoclave 3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Betschart, Claudia; Hintermann, Samuel; Behnke, Dirk; Cotesta, Simona; Fendt, Markus; Gee, Christine E.; Jacobson, Laura H.; Laue, Grit; Ofner, Silvio; Chaudhari, Vinod; Badiger, Sangamesh; Pandit, Chetan; Wagner, Juergen; Hoyer, Daniel
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7590 - 7607
