1: With lithium chloride; zinc in tetrahydrofuran T=50°C; 14 h; Inert atmosphere; 2: With water; ammonium chloride in tetrahydrofuran Inert atmosphere; regioselective reaction;

1: tert-butyl 2,4-dibromophenyl carbonate With lithium chloride; zinc in tetrahydrofuran T=50°C; 14 h; Inert atmosphere; 2: 3-iodo-α,α,α-trifluorotoluene With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=25°C; Negishi coupling reaction; 12 h; Inert atmosphere; regioselective reaction;