N,N-双(2-氯乙基)氨基甲酸叔丁酯合成路线

参考文献

SCHERING CORPORATION; BOGEN, Stephane, L.; MA, Yao; WANG, Yaolin; LAHUE, Brian Robert; NAIR, Latha, G.; SHIZUKA, Manami; VOSS, Matthew Ernst; KIROVA-SNOVER, Margarita; PAN, Weidong; TIAN, Yuan; KULKARNI, Bheemashankar, A.; GIBEAU, Craig, R.; LIU, Yuan; SCAPIN, Giovanna; RINDGEN, Diane; DOLL, Ronald, J.; GUZI, Timothy, J.; HICKLIN, Danny, J.; NOMEIR, Amin; SEIDEL-DUGAN, Cynthia; SHIPPS, Gerald, W., Jr.; MACCOSS, Malcolm
Patent: WO2011/46771 A1, 2011 ;
Location in patent: Page/Page column 139-140 ;
WO 2011/046771 A1

54401-85-34-吡啶乙酸乙酯+

118753-70-1N,N-双(2-氯乙基)氨基甲酸叔丁酯

954125-18-91-叔丁基 4-乙基 4-(吡啶-4-基)哌啶-1,4-二羧酸

参考文献

GRUENENTHAL GmbH
Patent: US2009/264407 A1, 2009 ;
Location in patent: Page/Page column 59-60 ;
US 20090264407 A1

7035-03-2邻甲氧基苯乙腈+

118753-70-1N,N-双(2-氯乙基)氨基甲酸叔丁酯

553631-31-51-N-Boc-4-氰基-4-(2-甲氧基苯基)哌啶

参考文献

Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780

118753-70-1N,N-双(2-氯乙基)氨基甲酸叔丁酯

553631-33-71-N-Boc-4-(3-氯苯基)-4-氰基哌啶

参考文献

ARRAY BIOPHARMA INC.; MITCHELL, Ian S.; BLAKE, James F.; XU, Rui; KALLAN, Nicholas C.; XIAO, Dengming; SPENCER, Keith Lee; BENCSIK, Josef R.
Patent: WO2008/6039 A1, 2008 ;
Location in patent: Page/Page column 92 ;
WO 2008/006039 A1

1529-41-5间氯氰苄+

118753-70-1N,N-双(2-氯乙基)氨基甲酸叔丁酯

553631-33-71-N-Boc-4-(3-氯苯基)-4-氰基哌啶

参考文献

GRUENENTHAL GmbH
Patent: US2009/264407 A1, 2009 ;
Location in patent: Page/Page column 68 ;
US 20090264407 A1

501-00-83-氟苯乙腈+

118753-70-1N,N-双(2-氯乙基)氨基甲酸叔丁酯

619292-30-7

参考文献

Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780

20870-78-45-溴氧化吲哚+

118753-70-1N,N-双(2-氯乙基)氨基甲酸叔丁酯

873779-30-71-Boc-5-溴-1,2-二氢-2-氧代-螺[3H-吲哚-3,4-哌啶]

参考文献

Vachal, Petr; Miao, Shouwu; Pierce, Joan M.; Guiadeen, Deodial; Colandrea, Vincent J.; Wyvratt, Matthew J.; Salowe, Scott P.; Sonatore, Lisa M.; Milligan, James A.; Hajdu, Richard; Gollapudi, Anantha; Keohane, Carol A.; Lingham, Russell B.; Mandala, Suzanne M.; Demartino, Julie A.; Tong, Xinchun; Wolff, Michael; Steinhuebel, Dietrich; Kieczykowski, Gerard R.; Fleitz, Fred J.; Chapman, Kevin; Athanasopoulos, John; Adam, Gregory; Akyuz, Can D.; Jena, Dhirendra K.; Lusen, Jeffrey W.; Meng, Juncai; Stein, Benjamin D.; Xia, Lei; Sherer, Edward C.; Hale, Jeffrey J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 2945 - 2959