4-溴-3,5-二氯三氟甲苯合成路线 （共 5 条）
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in acetic acid
反应条件
n-butyllithium in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane
参考文献
Otsuka Kagaku Kabushiki Kaisha
Patent: US5739083 A1, 1998 ;
反应条件
n-butyllithium; phosphoric acid in hexane; N,N-dimethyl-formamide
参考文献
Otsuka Kagaku Kabushiki Kaisha
Patent: US5739083 A1, 1998 ;
反应条件
1: 1-bromo-2,6-dichloro-4-trifluoromethylbenzene With iso-propylmagnesium bromide in tetrahydrofuran T=-10°C; 2: N,N-dimethyl-formamide in tetrahydrofuran 3: With ammonium chloride in tetrahydrofuran
参考文献
F. HOFFMANN-LA ROCHE AG; KOLCZEWSKI, Sabine; PINARD, Emmanuel
Patent: WO2011/23667 A1, 2011 ;
Location in patent: Page/Page column 34 ;
WO 2011/023667 A1
反应条件
hydrogenchloride; n-butyllithium in petroleum; diethyl ether; hexane; ethyl acetate
参考文献
May and Baker Limited
Patent: US5206257 A1, 1993 ;
