(4-溴苯)(2,2-二甲氧基乙基)硫合成路线 （共 8 条）
反应条件
sodium ethanolate in ethanol Substitution;
参考文献
Seed; Toyne; Goodby; Hird
Journal of Materials Chemistry, 2000 , vol. 10, # 9 p. 2069 - 2080
反应条件
in N,N-dimethyl-formamide
参考文献
Eisai Co., Ltd.
Patent: US5340833 A1, 1994 ;
US 5340833 A
参考文献
Proceedings - Indian Academy of Sciences, Section A, , # 36 p. 405,408
反应条件
PPA in chlorobenzene
参考文献
Takeuchi, Kumiko; Kohn, Todd J.; Sall, Daniel J.; Denney, Michael L.; McCowan, Jefferson R.; Smith, Gerry F.; Gifford-Moore, Donetta S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 5 p. 759 - 764
反应条件
1: 100 percent / PPA / chlorobenzene 2: 64 percent / CuBr, MeONa / dimethylformamide View Scheme
参考文献
Takeuchi, Kumiko; Kohn, Todd J.; Sall, Daniel J.; Denney, Michael L.; McCowan, Jefferson R.; Smith, Gerry F.; Gifford-Moore, Donetta S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 5 p. 759 - 764
反应条件
1: 42.35 g / PPA / chlorobenzene / 15 h / Heating 2: 90 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / 0 - 20 °C 3: 77 percent / aq. NaOH; Br2 / dioxane / 0 - 20 °C View Scheme
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
1: 42.35 g / PPA / chlorobenzene / 15 h / Heating 2: 90 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / 0 - 20 °C View Scheme
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
1.1: 90 percent / polyphosphoric acid / chlorobenzene / Heating 2.1: LDA / tetrahydrofuran / 0.5 h / -10 °C 2.2: 80 percent / I2 / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Seed; Toyne; Goodby; Hird
Journal of Materials Chemistry, 2000 , vol. 10, # 9 p. 2069 - 2080
