反应条件
1.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 0.17 h / 0 °C
1.2: 3.5 h
2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 3 h / 20 °C
3.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 0.17 h / Inert atmosphere
3.2: 1.17 h / 20 °C
4.1: dichloromethane / 0.5 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Madsen, Andreas S.; Olsen, Christian A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590
