N,N-二甲基甲酰胺二乙基缩醛合成路线 （共 152 条）
反应条件
in xylene
T=100°C; 7 h;
参考文献
Stezhko, T. V.; Granik, V. G.; Glushkov, R. G.; Roshchina, L. F.; Polezhaeva, A. I.; Mashkovskii, M. D.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 7 p. 478 - 482
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 7 p. 823 - 827
反应条件
aluminium trichloride in benzene
Heating;
参考文献
Smetskaya, N. I.; Mukhina, N. A.; Granik, V. G.; Shvarts, G. Ya.; Syubaev, R. D.; Mashkovskii, M. D.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 8 p. 540 - 544
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 8 p. 931 - 935
反应条件
in xylene
7 h; Heating;
参考文献
Dozorova, E. N.; Grizik, S. I.; Persianova, I. V.; Syubaev, R. D.; Shvarts, G. Ya.; Granik, V. G.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 2 p. 100 - 104
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 2 p. 154 - 158
反应条件
in 1,4-dioxane
T=80°C; 2 h;
参考文献
Blake, Alexander J.; McNab, Hamish; Murray, M. Elizabeth-Ann
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 589 - 595
反应条件
iodine in diethyl ether
2 h; Heating; Product distribution;
参考文献
Kantlehner, Willi; Hauber, Michael; Haug, Erwin; Schallenmueller, Claus; Regele, Claudia
Journal fuer Praktische Chemie - Practical Applications and Applied Chemistry (Germany), 2000 , vol. 342, # 7 p. 682 - 699
反应条件
in methanol
5 h; Ambient temperature;
参考文献
Koelle, Ulrich; Kolb, Bernd; Mannschreck, Albrecht
Chemische Berichte, 1980 , vol. 113, # 7 p. 2545 - 2565
反应条件
3 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249583 A1, 2007 ;
Location in patent: Page/Page column 162 ;
US 20070249583 A1
反应条件
in N,N-dimethyl-formamide
T=130 - 135°C;
参考文献
Xia, Zhiqiang; Przewloka, Teresa; Koya, Keizo; Ono, Mitsunori; Chen, Shoujun; Sun, Lijun
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8817 - 8820
反应条件
in tetrahydrofuran; water
参考文献
Hisamitsu Pharmaceutical Co., Inc.
Patent: US4016166 A1, 1977 ;
参考文献
IDENIX PHARMACEUTICALS, INC.
Patent: WO2009/14730 A1, 2009 ;
Location in patent: Page/Page column 132 ;
WO 2009/014730 A1
