n-[5-(甲苯磺酰氧基)戊基]氨基甲酸叔丁酯合成路线 （共 7 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C; 4.5 h;
参考文献
Otsuki, Satsuki; Nishimura, Shinichi; Takabatake, Hisae; Nakajima, Kozue; Takasu, Yasuaki; Yagura, Toru; Sakai, Yuki; Hattori, Akira; Kakeya, Hideaki
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1608 - 1611
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; water
参考文献
Isis Pharmaceuticals, Inc.
Patent: US6191273 B1, 2001 ;
反应条件
1: triethylamine / dichloromethane 2: triethylamine / dichloromethane View Scheme
参考文献
Sadovski, Oleg; Hicks, Justin W.; Parkes, Jun; Raymond, Roger; Nobrega, Jose; Houle, Sylvain; Cipriano, Mariateresa; Fowler, Christopher J.; Vasdev, Neil; Wilson, Alan A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4351 - 4357
反应条件
1: triethylamine / dichloromethane 2: triethylamine / dichloromethane View Scheme
参考文献
Sadovski, Oleg; Hicks, Justin W.; Parkes, Jun; Raymond, Roger; Nobrega, Jose; Houle, Sylvain; Cipriano, Mariateresa; Fowler, Christopher J.; Vasdev, Neil; Wilson, Alan A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4351 - 4357
反应条件
1: dichloromethane / 20 °C / |Cooling with ice 2: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 4.5 h / 0 - 20 °C View Scheme
参考文献
Otsuki, Satsuki; Nishimura, Shinichi; Takabatake, Hisae; Nakajima, Kozue; Takasu, Yasuaki; Yagura, Toru; Sakai, Yuki; Hattori, Akira; Kakeya, Hideaki
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1608 - 1611
反应条件
tetrabutylammomium bromide; sodium bromide in acetonitrile Reflux;
参考文献
Yoo, Barney; Cheal, Sarah M.; Torchon, Geralda; Dilhas, Anna; Yang, Guangbin; Pu, Jun; Punzalan, Blesida; Larson, Steven M.; Ouerfelli, Ouathek
Bioconjugate Chemistry, 2013 , vol. 24, # 12 p. 2088 - 2103
反应条件
sodium azide in N,N-dimethyl-formamide T=65 - 68°C; 6 h; Inert atmosphere;
参考文献
Kaschani, Farnusch; Clerc, Jerome; Krahn, Daniel; Bier, David; Hong, Tram Ngoc; Ottmann, Christian; Niessen, Sherry; Colby, Tom; Van Der Hoorn, Renier A. L.; Kaiser, Markus
Angewandte Chemie - International Edition, 2012 , vol. 51, # 21 p. 5230 - 5233
