(3-(4-溴苯基)氧杂环丁烷-3-基)甲醇合成路线 （共 4 条）
反应条件
potassium hydroxide; carbonic acid diethyl ester in ethanol T=110 - 200°C; 4 h;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0602 ;
反应条件
1.1: sodium ethanolate / N,N-dimethyl-formamide / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.33 h / 20 - 60 °C 2.2: |Cooling with ice 3.1: carbonic acid diethyl ester; potassium hydroxide / ethanol / 4 h / 110 - 200 °C View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.33 h / 20 - 60 °C 1.2: |Cooling with ice 2.1: carbonic acid diethyl ester; potassium hydroxide / ethanol / 4 h / 110 - 200 °C View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
1: With sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical in water; acetonitrile T=20°C; 16 h; 2: With sodium hydroxide in water; acetonitrile pH=10;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0603 ;
