3-甲氧基-4-氧代哌啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: 1,1-dimethylethyl 3,4,4-tris(methyloxy)-1-piperidinecarboxylate With hydrogenchloride in 1,4-dioxane T=50°C; 2: With water; sodium hydroxide in 1,4-dioxane pH=10; 3: di-tert-butyl dicarbonate in 1,4-dioxane 4 h;
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; WITTY, David R.; NORTON, David; TIERNEY, Jason Paul; LORTHIOIR, Ghislaine; SIME, Mairi; PHILPOTT, Karen Louise
Patent: WO2012/80735 A1, 2012 ;
Location in patent: Page/Page column 9; 32; 33 ;
WO 2012/080735 A1
反应条件
1.1: potassium hydroxide; iodine / 2.5 h / 0 - 20 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C 2.2: 0 - 20 °C 3.1: hydrogenchloride / 1,4-dioxane / 50 °C 3.2: pH 10 3.3: 4 h View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; WITTY, David R.; NORTON, David; TIERNEY, Jason Paul; LORTHIOIR, Ghislaine; SIME, Mairi; PHILPOTT, Karen Louise
Patent: WO2012/80735 A1, 2012 ;
WO 2012/080735 A1
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C 1.2: 0 - 20 °C 2.1: hydrogenchloride / 1,4-dioxane / 50 °C 2.2: pH 10 2.3: 4 h View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; WITTY, David R.; NORTON, David; TIERNEY, Jason Paul; LORTHIOIR, Ghislaine; SIME, Mairi; PHILPOTT, Karen Louise
Patent: WO2012/80735 A1, 2012 ;
WO 2012/080735 A1
