2,-三氟-(氟甲基)苯甲酸合成路线 (共 2 条)
反应条件
n-butyllithium; trifluoroacetic acid
参考文献
Warner-Lambert Company
Patent: US4780468 A1, 1988 ;
反应条件
1: 88 percent / SF6, HF (gas) / 8 h / 120 °C 2: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 5 min, 2.) Et2O, hexane, -78 deg C View Scheme
参考文献
Sanchez; Bridges; Bucsh; Domagala; Gogliotti; Hagen; Heifetz; Joannides; Sesnie; Shapiro; Szotek
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 361 - 367