3-甲酰基吡啶-2-羧酸异丙酯合成路线 （共 4 条）
反应条件
4 A molecular sieve; sodium acetate; pyridinium chlorochromate in dichloromethane 48 h; Ambient temperature;
参考文献
Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833
反应条件
1: 65 percent / 80 °C 2: SOCl2 / Heating 3: NaBH4 / tetrahydrofuran / 1 h / 0 °C 4: 43 percent / pyridinium chlorochromate, Na acetate, 4A-molecular sieves / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833
反应条件
1: NaBH4 / tetrahydrofuran / 1 h / 0 °C 2: 43 percent / pyridinium chlorochromate, Na acetate, 4A-molecular sieves / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833
反应条件
1: SOCl2 / Heating 2: NaBH4 / tetrahydrofuran / 1 h / 0 °C 3: 43 percent / pyridinium chlorochromate, Na acetate, 4A-molecular sieves / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833
