1: 92 percent / 1.) 5percent aq. NaOH; 2.) conc. HCl / 1 h / 25 °C 2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C 3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C 4: 1.) NaBH4; 2.) 4 M HCl / 1.) methanol, 25 deg C, 2 h; 2.) THF, 25 deg C, 1.5 h View Scheme

zinc(II) chloride; trichlorophosphate T=25°C; 2 h; Yield given;

1: 92 percent / 1.) 5percent aq. NaOH; 2.) conc. HCl / 1 h / 25 °C 2: 80 percent / K2CO3, KI / dimethylformamide / 2 h / 80 °C 3: 88 percent / K2CO3 / dimethylformamide / 15 h / 80 °C View Scheme