2,6-二[(4S)-4-叔丁基-2-恶唑啉基]吡啶合成路线 （共 5 条）
反应条件
1: With potassium hydrogencarbonate in isopropanol acetate T=80°C; Substitution; 2 h; 2: With boron trifluoride diethyl etherate T=125°C; Cyclization; 2 h; Further stages.;
参考文献
Schaus; Jacobsen
Organic letters, 2000 , vol. 2, # 7 p. 1001 - 1004
反应条件
zinc trifluoromethanesulfonate in toluene 48 h; Heating;
参考文献
Cornejo; Fraile; Garcia; Gil; Martinez-Merino; Mayoral; Pires; Villalba
Synlett, 2005 , # 15 art. no. G13005ST, p. 2321 - 2324
反应条件
zinc(II) chloride in chlorobenzene Addition; 24 h; Heating;
参考文献
Chelucci, Giorgio; Deriu, Sebastiane; Pinna, Gerard A.; Saba, Antonio; Valenti, Raffaela
Tetrahedron Asymmetry, 1999 , vol. 10, # 19 p. 3803 - 3809
反应条件
1.1: CHCl3 / 0 °C 2.1: thionyl chloride / Heating 2.2: 51 percent / aq. sodium hydroxide / methanol / 72 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 49 p. 8987 - 8990
反应条件
1.1: thionyl chloride / Heating 2.1: CHCl3 / 0 °C 3.1: thionyl chloride / Heating 3.2: 51 percent / aq. sodium hydroxide / methanol / 72 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 49 p. 8987 - 8990
