(S)-2-(1-苄基吡咯烷-2-基)丙烷-2-醇合成路线 （共 8 条）
反应条件
in tetrahydrofuran T=0°C; 3.5 h;
参考文献
Sibi, Mukund P.; Zhang, Ruzhou; Manyem, Shankar
Journal of the American Chemical Society, 2003 , vol. 125, # 31 p. 9306 - 9307
反应条件
1: in tetrahydrofuran T=0°C; 3.5 h; 2: With ammonium chloride in tetrahydrofuran
参考文献
AMGEN INC.; ALLEN, Jennifer R.; BOURBEAU, Matthew P.; CHEN, Ning; HU, Essa; KUNZ, Roxanne; RUMFELT, Shannon
Patent: WO2010/57121 A1, 2010 ;
Location in patent: Page/Page column 91-92 ;
WO 2010/057121 A1
反应条件
in diethyl ether 1.5 h; Heating;
参考文献
Bucher; Linden; Heimgartner
Helvetica Chimica Acta, 1995 , vol. 78, # 4 p. 935 - 946
反应条件
in tetrahydrofuran T=-78 - 20°C;
参考文献
Almansa, Raquel; Guijarro, David; Yus, Miguel
Tetrahedron Asymmetry, 2007 , vol. 18, # 23 p. 2828 - 2840
反应条件
1: 80 percent / EtN3 / CH2Cl2 / 4 h / 20 °C 2: 95 percent / tetrahydrofuran / 3.5 h / 0 °C View Scheme
参考文献
Hedenstroem, Erik; Andersson, Fredrik; Hjalmarsson, Mats
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 10 p. 1513 - 1518
反应条件
1: 80 percent / EtN3 / CH2Cl2 / 4 h / 20 °C 2: 95 percent / tetrahydrofuran / 3.5 h / 0 °C View Scheme
参考文献
Hedenstroem, Erik; Andersson, Fredrik; Hjalmarsson, Mats
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 10 p. 1513 - 1518
反应条件
1: 98.3 percent / NaH / tetrahydrofuran / -30 deg C to RT, reflux 2: 87 percent / H2 / 10 percent Pd/C / ethanol / Ambient temperature 3: t-BuONO / tetrahydrofuran / Heating 4: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
反应条件
1: 98.3 percent / NaH / tetrahydrofuran / -30 deg C to RT, reflux
2: 87 percent / H2 / 10 percent Pd/C / ethanol / Ambient temperature
View Scheme
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
