4-(叔丁基二甲基甲硅烷基氧基甲基)苄醇合成路线 （共 19 条）
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=-78°C; 0.5 h; 2: With ammonium chloride in diethyl ether; water; ethyl acetate
参考文献
Eli Lilly and Company; Wayne State University; University of Hawaii
Patent: US6680311 B1, 2004 ;
Location in patent: Page/Page column 150-151 ;
反应条件
1: α,α'-dihydroxy-p-xylene With 1H-imidazole in tetrahydrofuran cooling; 2: tert-butyldimethylsilyl chloride in tetrahydrofuran 12 h; Further stages.;
参考文献
Potter, Robert G.; Hughes, Thomas S.
Organic Letters, 2007 , vol. 9, # 7 p. 1187 - 1190
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 6 h;
参考文献
EVOTEC AG; DAVENPORT, Adam James; HALLETT, David James
Patent: WO2010/133544 A1, 2010 ;
Location in patent: Page/Page column 48 ;
WO 2010/133544 A1
反应条件
1H-imidazole in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Miyabe, Hideto; Konishi, Chihiro; Naito, Takeaki
Organic Letters, 2000 , vol. 2, # 10 p. 1443 - 1445
反应条件
sodium carbonate; bis(dibenzylideneacetone)-palladium(0); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in 1,4-dioxane; water Suzuki-Miyaura cross-coupling; 36 h; Inert atmosphereReflux;
参考文献
Murai, Norio; Yonaga, Masahiro; Tanaka, Keigo
Organic Letters, 2012 , vol. 14, # 5 p. 1278 - 1281
反应条件
H2SiF6; triethylamine in acetonitrile T=0°C; 1 h;
参考文献
Pilcher, Anthony S.; Hill, David K.; Shimshock, Stephen J.; Waltermire, Robert E.; DeShong, Philip
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2492 - 2495
反应条件
1: 71 percent / DMAP; Et3N / acetonitrile / 0.75 h 2: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Pilcher, Anthony S.; Hill, David K.; Shimshock, Stephen J.; Waltermire, Robert E.; DeShong, Philip
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2492 - 2495
反应条件
KF-Al2O3 (basic) in acetonitrile T=45 - 55°C; 48 h; ultrasound; Yield given;
参考文献
Schmittling, Elisabeth A.; Sawyer, J. Scott
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7207 - 7210
反应条件
1: 71 percent / DMAP; Et3N / acetonitrile / 0.75 h 2: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Pilcher, Anthony S.; Hill, David K.; Shimshock, Stephen J.; Waltermire, Robert E.; DeShong, Philip
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2492 - 2495
反应条件
1: sodium carbonate; bis(dibenzylideneacetone)-palladium(0); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine / 1,4-dioxane; water / 5 h / Inert atmosphere; Reflux 2: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C 3: sodium carbonate; bis(dibenzylideneacetone)-palladium(0); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine / 1,4-dioxane; water / 36 h / Inert atmosphere; Reflux View Scheme
参考文献
Murai, Norio; Yonaga, Masahiro; Tanaka, Keigo
Organic Letters, 2012 , vol. 14, # 5 p. 1278 - 1281
