1: 4-methyl-2-nitrophenol With sodium hydroxide in water 2: dimethyl sulfate With tetrabutylammomium bromide in dichloromethane; water T=10 - 25°C; 10 - 12 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.
Patent: WO2006/40650 A1, 2006 ;
Location in patent: Page/Page column 31-32 ;
WO 2006/040650 A1
Belyaev,E.Yu. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1972 , vol. 8, p. 8 - 9
Khimiya Geterotsiklicheskikh Soedinenii, 1972 , vol. 8, # 1 p. 10 - 11
1: 100 - 160 °C 2: tin dichloride; concentrated hydrochloric acid / Anfeuchten des Salzes mit Alkohol, Uebergiessen mit Aether und Einleiten von Ammoniak View Scheme
参考文献
Lellmann; Ebel
Chemische Berichte, 1895 , vol. 28, p. 1129
