反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere
1.2: 1.5 h / -78 - 20 °C / |Inert atmosphere
2.1: pyridine; thionyl chloride / dichloromethane / 3.17 h / 0 - 20 °C / |Inert atmosphere
3.1: potassium hydroxide / tetrahydrofuran; water / 48 h / 90 °C / |Inert atmosphere
4.1: 4-(N,N-dimethlyamino)pyridine; EDC monohydrochloride / dichloromethane / 12 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Meng, Lingkui; Kamada, Yuko; Muto, Kei; Yamaguchi, Junichiro; Itami, Kenichiro
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10048 - 10051
Angew. Chem., 2013 , vol. 125, # 38 p. 10232 - 10235,4