1: cyclopropyl bromide With magnesium in tetrahydrofuran
T=30 - 65°C; Inert atmosphere;
2: benzophenone in tetrahydrofuran
3: With acetyl chloride in tetrahydrofuran
参考文献
Parmar, Dixit; Duffy, Lorna A.; Sadasivam, Dhandapani V.; Matsubara, Hiroshi; Bradley, Paul A.; Flowers II, Robert A.; Procter, David J.
Journal of the American Chemical Society, 2009 , vol. 131, # 42 p. 15467 - 15473
1.1: nitric acid; sulfuric acid / 0.5 h / 75 °C
2.1: SnCl2; hydrochloric acid / 6 h / 70 °C
2.2: sodium nitrite; hydrochloric acid / H2O / 1 h / 0 °C
2.3: 33 percent / sulfuric acid; water / Heating
View Scheme
参考文献
Hejaz, Hatem A. M.; Woo, L. W. Lawrence; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2759 - 2772
Nakabayashi, Kenichi; Kojima, Jun-ichi; Tanabe, Kimiko; Yasuda, Masahide; Shima, Kensuke
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 96 - 101