2-氨基-1-(4-硝基苯基)-1,3-丙二醇合成路线 （共 90 条）
反应条件
sodium hydroxide in water T=5°C; 0.5 h;
参考文献
US2008/214821 A1, ;
Page/Page column 5 ;
参考文献
Journal of the American Chemical Society, , vol. 71, p. 2458,2459
反应条件
L-(-)-O,O'-dibenzoyltartaric acid Gewinnung von (1R,2R)-2-Amino-1-<4-nitro-phenyl>-<3-14C>propan-1,3-diol;
参考文献
Annali di Chimica (Rome, Italy), , vol. 43, p. 625
反应条件
sodium hydroxide Hydrolysis;
参考文献
Park, Jung Nam; Ko, Soo Y.; Koh, Hun Y.
Tetrahedron Letters, 2000 , vol. 41, # 29 p. 5553 - 5556
反应条件
1: 89 percent / NaNO2; AcOH / H2O / 2 h / 0 - 20 °C 2: 82 percent / diphenyl phosphoryl azide; DEAD; PPh3 / tetrahydrofuran / 12 h / 0 - 20 °C 3: 97 percent / H2 / Pd/C / methanol / 12 h / 20 °C / 760 Torr 4: 100 percent / DMAP; pyridine 5: HNO3; H2SO4 / 1.5 h / -20 - 20 °C 6: aq. HCl / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 10 p. 1743 - 1746
反应条件
1: 82 percent / diphenyl phosphoryl azide; DEAD; PPh3 / tetrahydrofuran / 12 h / 0 - 20 °C 2: 97 percent / H2 / Pd/C / methanol / 12 h / 20 °C / 760 Torr 3: 100 percent / DMAP; pyridine 4: HNO3; H2SO4 / 1.5 h / -20 - 20 °C 5: aq. HCl / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 10 p. 1743 - 1746
反应条件
1: 97 percent / H2 / Pd/C / methanol / 12 h / 20 °C / 760 Torr 2: 100 percent / DMAP; pyridine 3: HNO3; H2SO4 / 1.5 h / -20 - 20 °C 4: aq. HCl / 90 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 10 p. 1743 - 1746
反应条件
hydrogen bromide Hydrolysis;
参考文献
Journal of the American Chemical Society, , vol. 78, p. 3072
反应条件
1: Pd(PPh3)4 / benzene 2: H2 / Pd/CaCO3 3: titanium isopropoxide (TIP), (+)-diethyl tartrate ((+)-DET), tert-butyl hydroperoxide (TBHP) / 168 h / -20 °C 4: NaN3/silica gel / dimethylformamide / 80 °C 5: H2O, PPh3 / tetrahydrofuran View Scheme
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 11 p. 859 - 860
反应条件
1: H2 / Pd/CaCO3 2: titanium isopropoxide (TIP), (+)-diethyl tartrate ((+)-DET), tert-butyl hydroperoxide (TBHP) / 168 h / -20 °C 3: NaN3/silica gel / dimethylformamide / 80 °C 4: H2O, PPh3 / tetrahydrofuran View Scheme
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 11 p. 859 - 860
