2-氨基-1-(4-硝基苯基)-1,3-丙二醇合成路线 （共 90 条）
参考文献
Farbenfabr. Bayer
Patent: DE1008747 , 1955 ;
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate T=20°C; 6 h;
参考文献
Lu, Haige; Chanco, Emmanuel; Zhao, Huimin
Tetrahedron, 2012 , vol. 68, # 37 p. 7651 - 7654
反应条件
anschliessender partieller Hydrolyse mit aether.HCl und Umsetzung des danach erhaltenen Reaktionsprodukts mit Dichloressigsaeure-methylester in Methanol;
参考文献
Parke,Davis and Co.
Patent: US2791595 , 1953 ;
参考文献
Geipel
Journal fuer Praktische Chemie (Leipzig), 1959 , vol. <4> 9, p. 104
反应条件
1: 75 percent / 0.25 h / 160 °C / 0.5 Torr 2: 80 percent / isopropanol, Raney nickel / 0.33 h / Heating 3: 1.) conc. H2SO4, NaNO2, 2.) EtOH, Cu / 1.) H2O, 0-5 deg C, 3 h, 2.) 30 deg C 4: 72 percent / pyridine / 1.) 0 deg, 4 h, 2.) room temperature, overnight 5: 90 percent / triethyl ammonium iodide / 1.5 h / Heating 6: 90 percent / H2, Et3N / 10percent Pd/C / ethyl acetate / 760 Torr 7: 87 percent / 0.5percent NaOMe / methanol / 24 h / Ambient temperature 8: 80 percent / 92percent aq. hydrazine / ethanol / 0.75 h / Heating View Scheme
参考文献
Boerner, Armin; Krause, Hanswalter
Journal fuer Praktische Chemie (Leipzig), 1990 , vol. 332, # 3 p. 307 - 312
反应条件
triethylamine in dichloromethane
T=20°C; 24 h;
参考文献
El Moncef, Abdelkarim; El Hadrami, El Mestafa; Gonzalez, Miguel A.; Zaballos, Elena; Zaragoza, Ramon J.
Tetrahedron, 2010 , vol. 66, # 27-28 p. 5173 - 5184
反应条件
1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C
2.1: hydrogen / palladium 10 on activated carbon / methanol / 16 h / 20 °C
3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
3.2: 0 - 20 °C
4.1: sulfuric acid / 18 h / 105 °C
4.2: 20 °C / pH 13
5.1: triethylamine / anhydrous dichloroethane / Reflux
6.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C
7.1: hydrogenchloride; water; acetic acid / 16 h / 110 °C / Sealed tube
View Scheme
参考文献
RIB-X PHARMACEUTICALS, INC.; DUFFY, Erin, M.
Patent: WO2012/125832 A2, 2012 ;
WO 2012/125832 A2
反应条件
sodium carbonate in dichloromethane
cooling;
参考文献
Madesclaire; Zaitsev; Zaitseva; Sharipova
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 10 p. 1325 - 1332
反应条件
1: isoamyl alcohol
2: CrO3
View Scheme
参考文献
Schemjakin et al.
Zhurnal Obshchei Khimii, 1954 , vol. 24, p. 2076,2081; engl. Ausg. S. 2045, 2049
反应条件
1: 62 percent / Et3N / dimethylsulfoxide / 3 h / Ambient temperature
2: 0.30 g / 2,6-collidine / Ambient temperature
3: Jones reagent / acetic acid
View Scheme
参考文献
Gunda, Tamas E.; Sztaricskai, Ferenc
Tetrahedron, 1997 , vol. 53, # 23 p. 7985 - 7998
