4′-氨基-N-甲基乙酰苯胺合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol 12 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1813606 A1, 2007 ;
Location in patent: Page/Page column 91 ;
反应条件
hydroxylamine hydrochloride; sodium acetate in methanol T=20°C; 1 h; Inert atmosphere;
参考文献
Wang, Xi; Xu, Yan; Mo, Fanyang; Ji, Guojing; Qiu, Di; Feng, Jiajie; Ye, Yuxuan; Zhang, Songnan; Zhang, Yan; Wang, Jianbo
Journal of the American Chemical Society, 2013 , vol. 135, # 28 p. 10330 - 10333
反应条件
1: NaH / tetrahydrofuran / 20 °C 2: H2 / Pd-C / ethyl acetate; ethanol View Scheme
参考文献
Organic Letters, , vol. 5, # 8 p. 1265 - 1267
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / 20 °C 2: ammonium formate / palladium on activated charcoal / ethanol / 2 h / 20 °C / Inert atmosphere View Scheme
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate / toluene / 12 h / 80 °C / |Inert atmosphere; |Schlenk technique 2: sodium acetate; hydroxylamine hydrochloride / methanol / 1 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 28 p. 10330 - 10333
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C / |Inert atmosphere 1.2: 14 h / 20 °C / |Inert atmosphere 2.1: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate / toluene / 12 h / 80 °C / |Inert atmosphere; |Schlenk technique 3.1: sodium acetate; hydroxylamine hydrochloride / methanol / 1 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 28 p. 10330 - 10333
反应条件
1: HNO3+H2SO4 / 0 - 12 °C 2: iron; diluted acetic acid / 50 - 75 °C View Scheme
参考文献
Journal of the Chemical Society, , vol. 113, p. 690
反应条件
2: HNO3+H2SO4 / 0 - 12 °C 3: iron; diluted acetic acid / 50 - 75 °C View Scheme
参考文献
Journal of the Chemical Society, , vol. 113, p. 690
反应条件
2: aqueous HCl View Scheme
参考文献
Journal of the Chemical Society, , p. 3089,3092
反应条件
(i) aq. HCl, NaNO2, (ii) /BRN= 3574491/; Multistep reaction;
参考文献
Kreher,R.; Halpaap,R.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1977 , vol. 32, p. 1325 - 1330
