反应条件
1: 1.) NaH / 1.) DMF, room temp., 3 h; 2.) pH=8, room temp., 30 min
2: 93 percent / hydrogen / Raney-Ni / ethanol / 29 h / 20 °C
3: 1.) cc. HCl; 2.) aq. K2CO3 / 1.) AcOH, 2 deg C, 15 min; 2.) pH=6, 5 deg C, 2 h
4: 1.) aq. NaOH; 2.) aq. HCl / 1.) MeOH, room temp., 90 min; 2.) 0 deg C, 3 h, pH=2
5: 96 percent / cc. HBr / 22 h / 100 °C
6: 84 percent / HCl / 4 h / 0 °C
7: 85 percent / NaBH4 / methanol; tetrahydrofuran / 2 h / 25 °C
View Scheme
参考文献
Heckendorn, Roland
Helvetica Chimica Acta, 1987 , vol. 70, p. 2118 - 2129
