2, 2'-二硫代二苯甲酸合成路线 （共 163 条）
反应条件
1: pyridine, thionyl chloride / toluene / Heating
2: 80 percent / dioxane / 2.5 h / 10 °C
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
反应条件
1: pyridine, thionyl chloride / toluene / Heating
2: 80.1 percent / dioxane / 1.) 10 deg C, 1 h; 2.) room temp., 2 h
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
反应条件
sodium dithionite; water; sodium carbonate
参考文献
Hansch; Blondon
Journal of the American Chemical Society, 1948 , vol. 70, p. 1561
反应条件
sulfuric acid
1.) 20 h, 2.) heating, 1 h;
参考文献
Okabayashi; Kimura; Fujiwara; Kato
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 6 p. 2545 - 2549
反应条件
1: 84 percent / SOCl2 / 24 h / Heating
2: 24 percent / Et3N / CH2Cl2 / 18 h
View Scheme
参考文献
Domagala, John M.; Bader, John P.; Gogliotti, Rocco D.; Sanchez, Joseph P.; Stier, Michael A.; Song, Yuntao; Vara Prasad; Tummino, Peter J.; Scholten, Jeffrey; Harvey, Patricia; Holler, Tod; Gracheck, Steve; Hupe, Donald; Rice, William G.; Schultz, Robert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 569 - 579
反应条件
1: 84 percent / SOCl2 / 24 h / Heating
2: 26 percent / pyridine / 8 h / 10 °C
View Scheme
参考文献
Domagala, John M.; Bader, John P.; Gogliotti, Rocco D.; Sanchez, Joseph P.; Stier, Michael A.; Song, Yuntao; Vara Prasad; Tummino, Peter J.; Scholten, Jeffrey; Harvey, Patricia; Holler, Tod; Gracheck, Steve; Hupe, Donald; Rice, William G.; Schultz, Robert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 569 - 579
反应条件
1: SOCl2 / Heating
2: 82 percent / triethylamine / CH2Cl2 / 20 °C
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: thionyl chloride
2: 56.3 percent / dioxane / 3 h / Ambient temperature
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: thionyl chloride
2: 75.3 percent / dioxane / 2 h / Ambient temperature
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
反应条件
1: pyridine, thionyl chloride / toluene / Heating
2: 73.2 percent / dioxane / 1.) 11 deg C, 1 h; 2.) 40 deg C, 2 h
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
