2, 2'-二硫代二苯甲酸合成路线 （共 163 条）
反应条件
sulfuric acid
T=0 - 65°C; 2.5 h;
参考文献
Herr, Donald E.; Hu, Ziyi; Paul, Charles W.; Humphreys, Robert W.R.
Patent: US2003/236425 A1, 2003 ;
Location in patent: Page 8-9 ;
反应条件
1: 71 percent / SOCl2 / dimethylformamide; toluene / 18 h / 75 °C
2: Cl2 / CH2Cl2
3: concd NH4OH / CH2Cl2 / 1 h
4: 77 percent / POCl3 / 3.5 h / 20 - 120 °C
5: 68 percent / 24 h / 125 °C
6: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating
7: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating
View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
1: 1.) thionyl chloride, DMF, 2.) Cl2 gas / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 10 deg C, 20 min
2: SnCl4 / 12 h / Ambient temperature
View Scheme
参考文献
Honek, John F.; Manchini, Michael L.; Belleau, Bernard
Synthetic Communications, 1983 , vol. 13, # 12 p. 977 - 984
反应条件
1: 1.) thionyl chloride, DMF, 2.) Cl2 gas / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 10 deg C, 20 min
2: 50 percent / SnCl4 / 1,2-dichloro-ethane / 12 h / Ambient temperature
View Scheme
参考文献
Honek, John F.; Manchini, Michael L.; Belleau, Bernard
Synthetic Communications, 1983 , vol. 13, # 12 p. 977 - 984
反应条件
1: thionyl chloride
2: 94.1 percent / dioxane / 2 h / Ambient temperature
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
sulfuric acid
T=0 - 25°C; 1 h;
参考文献
Great Lakes (UK) Limited
Patent: EP1380580 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
1: 84 percent / SOCl2 / 24 h / Heating
2: 39 percent / pyridine / 8 h / 10 °C
View Scheme
参考文献
Domagala, John M.; Bader, John P.; Gogliotti, Rocco D.; Sanchez, Joseph P.; Stier, Michael A.; Song, Yuntao; Vara Prasad; Tummino, Peter J.; Scholten, Jeffrey; Harvey, Patricia; Holler, Tod; Gracheck, Steve; Hupe, Donald; Rice, William G.; Schultz, Robert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 569 - 579
反应条件
1: thionyl chloride
2: 64.8 percent / dioxane / 2 h / 40 °C
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: pyridine, thionyl chloride / toluene / Heating
2: 78 percent / dioxane / 1.) 10 deg C, 1 h; 2.) room temp., 2 h
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
反应条件
1: thionyl chloride
2: 88.4 percent / dioxane / 2 h
View Scheme
参考文献
Yamada; Niino; Hashimoto; Shuto; Nakamizo; Kubo; Ono; Murayama
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1214 - 1220
