2, 2'-二硫代二苯甲酸合成路线 （共 163 条）
反应条件
1: 89 percent / 1,3-diisopropylcarbodiimide / tetrahydrofuran; propan-2-ol / 4 h / 20 °C
2: 91 percent / 4-methylmorpholine / N,N-dimethyl-acetamide / 20 °C
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: thionyl chloride
2: 80.3 percent / dioxane / 2 h / Ambient temperature
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: thionyl chloride
2: 74.8 percent / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: thionyl chloride
2: 75.5 percent / dioxane / 2 h / Ambient temperature
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: thionyl chloride
2: 94.3 percent / dioxane / 2 h / 40 °C
View Scheme
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
1: thionyl chloride / Reflux
2: chlorine / tetrachloromethane / 20 °C
3: dichloromethane / 2 h / -15 - 20 °C
View Scheme
参考文献
Pietka-Ottlik, Magdalena; Potaczek, Piotr; Piasecki, Egbert; Mlochowski, Jacek
Molecules, 2010 , vol. 15, # 11 p. 8214 - 8228
反应条件
1: 280 °C / im Rohr
2: sulfuric acid
View Scheme
参考文献
Hinsberg
Chemische Berichte, 1910 , vol. 43, p. 1875
反应条件
1: 84 percent / SOCl2 / 24 h / Heating
2: 84 percent / Et3N / CH2Cl2 / 18 h
View Scheme
参考文献
Domagala, John M.; Bader, John P.; Gogliotti, Rocco D.; Sanchez, Joseph P.; Stier, Michael A.; Song, Yuntao; Vara Prasad; Tummino, Peter J.; Scholten, Jeffrey; Harvey, Patricia; Holler, Tod; Gracheck, Steve; Hupe, Donald; Rice, William G.; Schultz, Robert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 569 - 579
反应条件
(i) SOCl2, dioxane, (ii) /BRN= 606077/; Multistep reaction;
参考文献
Wagner,G.; Richter,P.
Pharmazie, 1967 , vol. 22, p. 611 - 620
参考文献
Domagala, John M.; Bader, John P.; Gogliotti, Rocco D.; Sanchez, Joseph P.; Stier, Michael A.; Song, Yuntao; Vara Prasad; Tummino, Peter J.; Scholten, Jeffrey; Harvey, Patricia; Holler, Tod; Gracheck, Steve; Hupe, Donald; Rice, William G.; Schultz, Robert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 569 - 579
