2, 2'-二硫代二苯甲酸合成路线 （共 163 条）
反应条件
sodium hydroxide
T=25°C; 3 h;
参考文献
Jin, Chun Keun; Moon, Jung-Kyen; Lee, Woo Song; Nam, Keun Soo
Synlett, 2003 , # 13 p. 1967 - 1968
参考文献
Gilman; Arntzen; Webb
Journal of Organic Chemistry, 1945 , vol. 10, p. 374,378
Full Text Show Details
Gilman; Webb
Journal of the American Chemical Society, 1949 , vol. 71, p. 4062,4063
参考文献
List; Stein
Chemische Berichte, 1898 , vol. 31, p. 1668
反应条件
1: (i) SOCl2, dioxane, (ii) NH3
2: Zn, aq. HCl
View Scheme
参考文献
Wagner,G.; Richter,P.
Pharmazie, 1967 , vol. 22, p. 611 - 620
反应条件
sulfuric acid
T=-5 - 70°C; 21 h;
参考文献
AGFA-GEVAERT; LOCCUFIER, Johan
Patent: WO2012/52288 A1, 2012 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: 68 percent / thionyl chloride / 14 h / Heating
2: 80 percent / pyridine / 1.5 h / Heating
View Scheme
参考文献
Seyedi, Seyed Mohammad; Shadkam; Ziafati
Phosphorus, Sulfur and Silicon and the Related Elements, 2005 , vol. 180, # 8 p. 1953 - 1960
反应条件
1: 85 percent / hydriodic acid, hypophosphorous acid, conc. hydrochloric acid / 3 h / Heating
2: acetic acid
3: SOCl2 / 3 h / 50 - 60 °C
View Scheme
参考文献
Bhatt, M. Vivekananda; El Ashry, Shaker H.; Somayaji, Vishwanatha
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 6 p. 473 - 486
反应条件
1.1: thionyl chloride / 3 h / 80 °C
1.2: 0.5 h / 50 °C
2.1: dichloromethane / 3 h / 20 °C
View Scheme
参考文献
He, Jie; Li, Dongdong; Xiong, Kun; Ge, Yongjie; Jin, Hongwei; Zhang, Guozhou; Hong, Mengshi; Tian, Yongliang; Yin, Jin; Zeng, Huihui
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3816 - 3827
反应条件
1: With thionyl chloride; 1-methyl-pyrrolidin-2-one
T=80°C; Heating / reflux;
2: With sulfuryl dichloride
T=50°C; 0.5 h;
参考文献
Berg, Carsten
Patent: US2003/229233 A1, 2003 ;
Location in patent: Page 3 ;
参考文献
Prescott; Smiles
Journal of the Chemical Society, 1911 , vol. 99, p. 645
