2, 2'-二硫代二苯甲酸合成路线 （共 163 条）
反应条件
sulfuric acid T=50°C;
参考文献
Marsden; Smiles
Journal of the Chemical Society, 1911 , vol. 99, p. 1356
反应条件
1: 1.) thionyl chloride, DMF, 2.) Cl2 gas / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 10 deg C, 20 min 2: 72 percent / SnCl4 / 12 h / Ambient temperature View Scheme
参考文献
Honek, John F.; Manchini, Michael L.; Belleau, Bernard
Synthetic Communications, 1983 , vol. 13, # 12 p. 977 - 984
反应条件
1: SOCl2 / 1 h / Heating 2: 147 g / benzene; tetrahydrofuran / 0 - 20 °C 3: 40 percent / Zn; AcOH / 6 h / Heating View Scheme
参考文献
Wagner,G.; Richter,P.
Pharmazie, 1967 , vol. 22, p. 611 - 620
反应条件
1: SOCl2 / 1 h / Heating 2: 147 g / benzene; tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Pietka-Ottlik, Magdalena; Potaczek, Piotr; Piasecki, Egbert; Mlochowski, Jacek
Molecules, 2010 , vol. 15, # 11 p. 8214 - 8228
反应条件
(i) SOCl2, dioxane, (ii) /BRN= 741851/; Multistep reaction;
参考文献
Wagner,G.; Richter,P.
Pharmazie, 1967 , vol. 22, p. 611 - 620
反应条件
1: 71 percent / SOCl2 / dimethylformamide; toluene / 18 h / 75 °C 2: Cl2 / CH2Cl2 3: concd NH4OH / CH2Cl2 / 1 h 4: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 5: 68 percent / 24 h / 125 °C View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
1: 71 percent / SOCl2 / dimethylformamide; toluene / 18 h / 75 °C 2: Cl2 / CH2Cl2 3: concd NH4OH / CH2Cl2 / 1 h 4: 77 percent / POCl3 / 3.5 h / 20 - 120 °C View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
参考文献
Hoechster Farbw.
Patent: DE69073 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 903
参考文献
Hoechster Farbw.
Patent: DE69073 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 903
反应条件
sulfuric acid T=20°C; 0.5 h;
参考文献
First Chemical Corporation
Patent: EP1211252 A1, 2002 ;
Location in patent: Page 6 ;
